There exists a release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors within the dorsal horn to decrease afferent ache transmission and deliver analgesia. Hence, medications like clonidine that focus on alpha-2 receptors can affect the transmission of pain. Clonidine is distributed in breast milk; https://devinpjape.worldblogged.com/38076827/the-definitive-guide-to-onolidine