Subacute toxicity scientific studies in canines for 4 months at 480 mg/kg day by day showed no specific changes; at 960 mg/kg, two out of 8 died with evidence of circulatory collapse. This broad margin of safety is important compared to chlordiazepoxide HCl, which showed nonspecific changes in six puppies https://deansvtrn.tribunablog.com/facts-about-oxazepam-kruidvat-revealed-44513604