Pentobarbital will decrease the extent or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Mysterious. pentobarbital will lower the extent or effect of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified. Contraindicated (1)pentobarbital will decrease the level or impact of... https://sodium-pentobarbital-sigm54724.thezenweb.com/not-known-factual-statements-about-pentobarbital-sodium-for-dogs-59245266